| Prelims: mRNA Technology, Cancer Vaccines, Messenger RNA, Neoantigens, Melanoma, Immunotherapy, Immune Checkpoint Inhibitors, PD-1, Precision Medicine, Biotechnology. Mains: GS Paper II: Health and Healthcare, Cancer Burden, Accessibility and Affordability of Advanced Healthcare, Public Health Challenges. GS Paper III: Science and Technology, Biotechnology, mRNA Technology, Genomics, Precision Medicine, Emerging Medical Technologies, Research and nnovation. |
A personalized mRNA-based cancer vaccine, called intismeran autogene (V940/mRNA-4157), jointly developed by Moderna and Merck, has achieved a major milestone in cancer treatment.
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mRNA |
Messenger RNA carries genetic instructions that cells use for making proteins. |
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Neoantigen |
An abnormal antigen generated by tumour-specific mutations that can potentially be recognized as foreign by the immune system. |
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Immunotherapy |
Treatment that uses or modifies the body's immune system to fight diseases such as cancer. |
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Immune Checkpoint Inhibitor |
A therapy that blocks inhibitory immune pathways, helping immune cells maintain or restore their ability to attack cancer. |
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PD-1 |
An immune checkpoint receptor found on immune cells, particularly T cells. |
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Melanoma |
A cancer arising from pigment-producing melanocytes, most commonly in the skin. |
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Feature |
Details |
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Therapy |
Intismeran autogene |
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Earlier name |
mRNA-4157 / V940 |
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Technology |
Messenger RNA (mRNA) |
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Type |
Individualized Neoantigen Therapy |
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Developers |
Moderna and Merck |
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Cancer studied |
High-risk resected melanoma |
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Combination drug |
Keytruda (Pembrolizumab) |
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Keytruda type |
Anti-PD-1 immunotherapy |
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Major trial |
INTerpath-001 |
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Trial phase |
Phase 3 |
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Main goal |
Prevent cancer recurrence and spread |
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Targets |
Up to 34 patient-specific tumour mutations |
Cancer develops when genetic changes cause cells to grow uncontrollably. These mutations can lead cancer cells to produce abnormal proteins or neoantigens that distinguish them from healthy cells.
Intismeran identifies and teaches the immune system what to attack, while Keytruda helps remove an immune “brake” that can prevent T cells from attacking effectively.
In August 2026, Moderna and Merck announced that the trial met its primary endpoint of recurrence-free survival (RFS) and the important secondary endpoint of distant metastasis-free survival (DMFS). The breakthrough establishes strong evidence for the approach in resected high-risk melanoma, not for all cancers.
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Preventive Vaccine |
Personalized Cancer Vaccine |
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Given mainly before disease develops |
Given to a cancer patient |
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Prevents cancer-causing infection |
Helps immune system target existing/residual cancer |
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Usually same formulation for many people |
Designed individually for each patient |
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Eg: HPV vaccine |
Eg: Intismeran autogene |
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Targets infectious agents/antigens |
Targets tumour-specific neoantigens |
It carries genetic instructions that cells use to produce proteins. For personalized cancer treatment, mRNA offers several advantages:
According to IARC's GLOBOCAN 2022 estimates, India recorded approximately 1.41 million new cancer cases, and 916,827 cancer deaths in 2022. The emergence of personalized mRNA cancer vaccines is relevant in several ways.
Prelims MCQQ. Intismeran autogene, recently seen in the news, is associated with: (A) Prevention of HIV infection Main Practice QuestionQ. Recent advances in personalized mRNA-based cancer vaccines have opened new possibilities in cancer treatment. Explain the role of mRNA technology in cancer immunotherapy. What challenges could limit its widespread adoption in countries like India? |
What is a personalized mRNA cancer vaccine?It uses a patient’s tumour mutations to train the immune system to attack cancer cells. What is intismeran autogene?It is an experimental personalized mRNA cancer therapy developed by Moderna and Merck. Which cancer is it being tested against?It is being tested mainly against high-risk melanoma. Is it the world’s first cancer vaccine?Sipuleucel-T, approved in 2010, was the first FDA-approved therapeutic cancer vaccine. What is the role of Keytruda?It blocks the PD-1 pathway, helping immune cells attack cancer. |
| Prelims: Pradhan Mantri Jan Dhan Yojana (PMJDY), Financial Inclusion, JAM Trinity, RuPay Card, Direct Benefit Transfer (DBT) Mains – GS Paper III: Inclusive Growth, Financial Inclusion, Digital Payments, Direct Benefit Transfer, Government Welfare Schemes Keywords: PM Jan Dhan Yojana 12 Years, PMJDY 2026, Pradhan Mantri Jan Dhan Yojana, PMJDY 12th Anniversary, PMJDY Benefits, PMJDY Accounts, Financial Inclusion in India, JAM Trinity, Direct Benefit Transfer (DBT), RuPay Card, Digital Payments, Rural Banking, Women Financial Inclusion, Inclusive Growth |
The Pradhan Mantri Jan Dhan Yojana (PMJDY) completed 12 years on 28 August 2026.
PMJDY has recorded significant growth in both accounts and deposits over the last 12 years.
This growth indicates greater use of Jan Dhan accounts and increasing saving habits among account holders.
PMJDY has significantly expanded banking access for women and people in rural and semi-urban areas.
JAM stands for Jan Dhan–Aadhaar–Mobile. It connects: Jan Dhan Account + Aadhaar + Mobile
PMJDY has helped expand digital payments and banking access across India.
PMJDY helps account holders move beyond basic banking towards formal credit and financial opportunities.
Despite its success, PMJDY still faces some challenges:
The next phase should focus on moving from bank account access to active and meaningful use of financial services.
PMJDY has expanded beyond basic banking to support inclusive economic growth.
Overall, PMJDY helps ensure that the benefits of India's economic and digital growth reach previously underserved sections of society.
After 12 years, PMJDY has become a key pillar of India's financial inclusion journey, bringing millions of people into the formal banking system. Going forward, the focus should shift from opening bank accounts to their active use, along with better access to credit, insurance, pensions and secure digital services, ensuring greater financial empowerment and inclusive growth.
Prelims Practice QuestionQ1. Pradhan Mantri Jan Dhan Yojana (PMJDY) was launched in which year? Mains Practice Question“Pradhan Mantri Jan Dhan Yojana (PMJDY) has transformed financial inclusion from mere bank account access to broader financial empowerment.” Discuss the achievements of PMJDY and the challenges that remain in achieving meaningful financial inclusion in India. |
1. What is PMJDY?PMJDY is a National Mission for Financial Inclusion that provides access to basic banking and financial services. 2. When was PMJDY launched?It was launched on 28 August 2014. 3. How many PMJDY accounts have been opened?As of 19 August 2026, 59.09 crore accounts had been opened. 4. How much money is deposited in PMJDY accounts?Total deposits stood at about ₹3.17 lakh crore as of 19 August 2026. 5. What is JAM Trinity?JAM stands for Jan Dhan–Aadhaar–Mobile, which supports direct and efficient delivery of government benefits. |
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Reform |
New Provision |
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One-time authorisation |
Eligible exporters can self-generate export authorisations for multiple consignments of specified defence items |
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OGEL validity |
Increased from 2 years to 3 years |
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Country coverage |
Expanded from 41 countries to all countries, subject to specified exclusions |
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Consolidation of SOPs |
Three existing OGEL SOPs have been merged into a single framework |
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International tenders & exhibitions |
Stakeholder consultation requirement removed for exports for such purposes |
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Non-lethal defence items |
Export procedures simplified for most destinations |
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FOEM agreements |
Special OGEL provision for companies having long-term agreements with foreign OEMs |
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Additional items |
Certain civil-end-use parts and components of small-calibre arms and protective equipment brought under OGEL |
The validity of OGEL has been increased from two years to three years, reducing the frequency of renewals. Its geographical coverage has also been expanded from 41 countries to all countries, except:
The reforms are expected to provide several benefits:
The reforms come against the backdrop of significant growth in India's defence manufacturing and exports.
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Indicator |
2025–26 |
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Defence Production |
₹1.78 lakh crore |
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Defence Exports |
₹38,424 crore |
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Status |
Record high |
The rising figures reflect India's broader efforts to promote Aatmanirbhar Bharat in Defence, expand domestic manufacturing and establish India as a reliable global defence supplier.
The simplification of defence export and licensing procedures is an important step towards making India's defence industry more competitive, export-oriented and globally integrated. By reducing repetitive approvals and expanding the OGEL framework, the government aims to improve the ease of doing business for defence manufacturers while retaining safeguards for sensitive technologies and destinations.
Overall, the reforms support India's broader objective of moving from being primarily a defence importer to a competitive global defence exporter.
UPSC Prelims MCQs :-Q1. With reference to the Open General Export Licence (OGEL), consider the following statements:
Which of the statements given above is/are correct? A. 1 and 2 only |
1. Why has the Centre eased defence export norms?The government has simplified defence export procedures to reduce regulatory delays, lower compliance requirements and help Indian defence manufacturers access global markets more quickly. 2. What is the Open General Export Licence (OGEL)?OGEL is a standing, one-time authorisation that allows eligible Indian exporters to export specified defence items through multiple consignments without seeking separate approval for every shipment. |
| Prelims: Great Lakes of North America, Lake Ontario, U.S.–Canada Boundary, St. Lawrence River, Niagara River, Trans boundary Water Bodies, North American Geography Mains: GS Paper I: World Geography-Important Lakes, Rivers and Physical Geography of North America GS Paper II: U.S.-Canada Relations, Bilateral Relations, Sovereignty and Trans boundary Cooperation |
U.S. President Donald Trump signed an executive order on 27 August 2026 directing the U.S. federal government to rename Lake Ontario as “Lake America.” The order requires the U.S. Department of the Interior and the U.S. Board on Geographic Names to implement the change in federal geographic records.
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Topic |
Fact |
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Original Name |
Lake Ontario |
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New U.S. Federal Name |
Lake America |
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Order Signed |
27 August 2026 |
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Executive Order |
EO 14420 |
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Canada’s Position |
Continues to recognise Lake Ontario |
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Lake Shared By |
United States & Canada |
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U.S. State Bordering Lake |
New York |
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Canadian Province |
Ontario |
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Lake Group |
Great Lakes |
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Number of Great Lakes |
5 |
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Easternmost Great Lake |
Lake Ontario |
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Major Outflow |
St. Lawrence River system |
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Surface Area |
~18,960 sq km |
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Maximum Depth |
~244 m |
Prelims MCQQ. Lake Ontario primarily drains into which river? (A) Mississippi River (B) Colorado River (C) St. Lawrence River (D) Columbia River Mains Practice QuestionQ. The controversy over the U.S. decision to rename Lake Ontario as “Lake America” highlights the diplomatic sensitivity associated with shared geographical features. Discuss in the context of U.S.–Canada relations and transboundary cooperation. |
Where is Lake Ontario located?It lies on the U.S.–Canada border, between the Canadian province of Ontario and the U.S. state of New York. Is Lake Ontario one of the Great Lakes?It is one of the five Great Lakes—Superior, Michigan, Huron, Erie and Ontario. What was Canada’s response?Canadian Prime Minister Mark Carney rejected the renaming and said Canada would continue to call it Lake Ontario. Can the United States force Canada to use the name “Lake America”?No. A U.S. executive order can determine U.S. federal usage, but it cannot compel Canada to adopt the same geographic name. Which river drains Lake Ontario?Lake Ontario drains into the St. Lawrence River, which flows toward the Atlantic Ocean. |
| Prelims: Javelin Missile, Anti-Tank Guided Missile (ATGM), fire-and-forget technology, top-attack capability, M777 Howitzer, Excalibur projectile, India-US defence cooperation. Mains – GS Paper II: India-US relations, strategic partnership, Indo-Pacific cooperation. Mains – GS Paper III: Defence technology, military modernisation, indigenisation of defence production, Make in India and Atmanirbhar Bharat. Keywords: Javelin ATGM, FGM-148, Anti-Tank Missile, Fire-and-Forget, Top-Attack, Armoured Warfare, India-US Defence Partnership, Defence Co-production, Military Modernisation, Defence Indigenisation, Make in India, Atmanirbhar Bharat. |
India plans to acquire the US-made Javelin Anti-Tank Guided Missile (ATGM) to strengthen the Indian Army’s ability to counter tanks and armoured vehicles.
The FGM-148 Javelin is a US-made, man-portable Anti-Tank Guided Missile (ATGM) designed mainly to destroy tanks and armoured vehicles.
Top-attack capability allows the Javelin missile to strike a tank from above rather than from the front.
The M982 Excalibur is a US-made precision-guided artillery projectile designed to strike targets with high accuracy.
The proposed Javelin missile acquisition will strengthen India’s anti-tank capability and deepen India-US defence cooperation. Possible future co-production could also support Make in India and Atmanirbhar Bharat in the defence sector.
Prelims Practice QuestionThe Javelin missile system is associated with which country? Mains practice questionHow can the acquisition of the Javelin Anti-Tank Guided Missile System strengthen the operational capabilities of the Indian Army? Discuss. |
1. What is the Javelin missile?-The FGM-148 Javelin is a US-made, man-portable Anti-Tank Guided Missile (ATGM). 2. What is the main purpose of Javelin?It is primarily designed to destroy tanks and armoured vehicles. 3. What is fire-and-forget technology?It means that after launch, the missile can guide itself toward the locked target, without continuous guidance from the operator. 4. What is Javelin's top-attack capability?It allows the missile to strike a tank from above, where armour is generally more vulnerable. 5. What is a Command Launch Unit (CLU)?It is the Javelin's reusable target-detection, aiming and missile-launching unit. |
| Prelims: Indian Railways, RVNL, Navratna CPSE, Ministry of Railways, Rishikesh–Karnaprayag Railway Project, Uttarakhand, Char Dham, Himalayan Connectivity. Mains – GS Paper III: Infrastructure – Railways, Transport Infrastructure, Regional Connectivity, Border Infrastructure, Tourism Infrastructure, Economic Development, Himalayan Infrastructure, Disaster Resilience, Sustainable Development. Mains – GS Paper II: Government Policies and Interventions, Role of Public Sector Enterprises in Infrastructure Development. Keyword: Rishikesh–Karnaprayag Railway, RVNL, Uttarakhand, Indian Railways, Himalayan Connectivity, Char Dham, Railway Tunnels, Border Connectivity, Tourism, Regional Development |
The Rishikesh–Karnaprayag Railway Project is a 125-km railway line being constructed to improve connectivity in the Himalayan region of Uttarakhand.
Since the railway passes through the mountainous terrain of Uttarakhand, tunnels form a major part of the project.
The Rishikesh–Karnaprayag Railway Project will significantly improve connectivity in Uttarakhand’s Himalayan region. Once completed, it will reduce travel time, support Char Dham tourism, boost the local economy and improve connectivity to remote and strategically important areas.
Prelims Practice QuestionQ1. The Rishikesh–Karnaprayag Railway Project is located in which state? Mains Practice QuestionsDiscuss The Significance Of The Rishikesh–Karnaprayag Railway Project for connectivity, tourism and economic development in Uttarakhand. |
1. What is the Rishikesh–Karnaprayag Railway Project?It is a 125-km railway line being developed to improve rail connectivity in Uttarakhand's Himalayan region. 2. When is the project expected to be completed?The project is targeted for completion by December 2029. 3. Who is implementing the project?The project is being implemented by Rail Vikas Nigam Limited (RVNL). 4. What is the estimated cost of the project?The estimated project cost is around ₹37,000 crore. 5. How many districts does the railway line pass through?It passes through five districts—Dehradun, Tehri Garhwal, Pauri Garhwal, Rudraprayag and Chamoli. |
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